PHENYLPHOSPHONIC ACID DIMETHYL ESTER synthesis
- Product Name:PHENYLPHOSPHONIC ACID DIMETHYL ESTER
- CAS Number:2240-41-7
- Molecular formula:C8H11O3P
- Molecular Weight:186.14
88284-48-4
171 suppliers
$9.00/250mg
868-85-9
278 suppliers
$25.00/5 g
2240-41-7
88 suppliers
$7.00/1g
Yield: 93%
Reaction Conditions:
with caesium carbonate;cesium fluoride in acetonitrile at 100; for 12 h;Sealed tube;
Steps:
4.3. General procedures for the reaction of o-(trimethylsilyl)aryl triflate with dialkyl phosphate
General procedure: In a typical reaction, to an oven-dried 25 mL heavy walled sealtube fitted with Teflon plug valve was added CsF (0.60 mmol),Cs2CO3 (0.90 mmol), o-(trimethylsilyl)aryl triflate (0.30 mmol) anddialkyl phosphate (0.32 mmol). MeCN (3 mL) was added via a syringe. The tube was sealed with Teflon plug valve and then thereaction mixture was stirred at 100 C for 12 h. The reaction wasallowed to cool to room temperature. Then reaction mixture wasdiluted with 5 mL water. The aqueous layer was extracted withethyl acetate (35 mL). The combined organic layers were driedover Na2SO4, filtered and concentrated. The product was isolatedthrough preparative thin-layer chromatography.
References:
Yang, Guoqiang;Shen, Chaoren;Quan, Mao;Zhang, Wanbin [Tetrahedron,2016,vol. 72,# 2,p. 333 - 337] Location in patent:supporting information
88284-48-4
171 suppliers
$9.00/250mg
121-45-9
234 suppliers
$14.00/5g
2240-41-7
88 suppliers
$7.00/1g
824-72-6
214 suppliers
$15.00/25 g
2240-41-7
88 suppliers
$7.00/1g
824-72-6
214 suppliers
$15.00/25 g
67-56-1
756 suppliers
$7.29/5ml-f
2240-41-7
88 suppliers
$7.00/1g