PHENYL-PYRIDIN-3-YL-METHANOL synthesis
- Product Name:PHENYL-PYRIDIN-3-YL-METHANOL
- CAS Number:6270-47-9
- Molecular formula:C12H11NO
- Molecular Weight:185.22
5424-19-1
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6270-47-9
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Yield:6270-47-9 100%
Reaction Conditions:
with sodium tetrahydridoborate in ethanol at 25; for 2 h;
Steps:
81.1 Step 1 Phenyl (pyridin-3-yl) methanol
A mixture of phenyl (pyridin-3-yl) methanone (2.0 g, 11 mmol) and sodium borohydride (623 mg, 16 mmol) in EtOH (30 mL) was stirred at 25 for 2 h. The mixture was then concentrated, diluted with water (20 mL) and extracted with EtOAc (20 mL × 3) . The combined organic layers were washed with brine (20 mL) , dried over anhydrous sodium sulfate, filtered and concentrated to give the desired product (2.0 g, 100) as yellow oil. LCMS (ESI) : m/z 184.3 [M+H]+.
References:
WO2015/78374,2015,A1 Location in patent:Page/Page column 206
500-22-1
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100-58-3
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6270-47-9
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626-55-1
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100-52-7
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6270-47-9
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500-22-1
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100-59-4
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6270-47-9
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89667-09-4
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6270-47-9
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