![873055-57-3](/CAS/GIF/873055-57-3.gif)
Phenol, 2,4-bis(1,1-diMethylethyl)-5-nitro- synthesis
- Product Name:Phenol, 2,4-bis(1,1-diMethylethyl)-5-nitro-
- CAS Number:873055-57-3
- Molecular formula:C14H21NO3
- Molecular Weight:251.32
![2,4-di-tert-butyl-5-nitrophenyl methyl carbonate](/CAS/GIF/873055-55-1.gif)
873055-55-1
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$60.00/50mg
![Phenol, 2,4-bis(1,1-diMethylethyl)-5-nitro-](/CAS/GIF/873055-57-3.gif)
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Yield: 98%
Reaction Conditions:
with sodium hydroxide in methanol;water at 20; for 5 h;
Steps:
1 Preparation of Compound 4 (2,4-di-tert-butyl-5-nitrophenol)
To a stirred solution of compound 3 (3.0 g, 9.7 mmol) in MeOH (20 mL) was added NaOH (776 mg, 19.4 mmol) dissolved in H2O (5 mL), and the reaction mixture was stirred at room temperature for 5 h and acidified with aq.2N HCl to pH 2-3. The resulting precipitate was collected by suction filtration. The desired regioisomer, compound 4 (2.4 g, 98%) was obtained as pale yellow solid and used in the next step after drying under high vacuum. 1H NMR (400 MHz, CDCl3) δ7.42 (s, 1H), 6.69 (s, 1H), 5.20 (s, 1H), 1.41 (s, 9H), 1.38 (s, 9H).
References:
ORPHOMED, INC.;SINGH, Nikhilesh Nihala US2021/9556, 2021, A1 Location in patent:Paragraph 0057; 0060
![2,4-Di-tert-butylphenol](/CAS/GIF/96-76-4.gif)
96-76-4
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![Phenol, 2,4-bis(1,1-diMethylethyl)-5-nitro-](/CAS/GIF/873055-57-3.gif)
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![2,4-di-tert-butyl-5-nitrophenyl methyl carbonate](/CAS/GIF/873055-55-1.gif)
873055-55-1
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$60.00/50mg
![Carbonic acid 2,4-di-tert-butyl-6-Nitro-phenyl ester Methyl ester](/CAS/20150408/GIF/873055-56-2.gif)
873055-56-2
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![Phenol, 2,4-bis(1,1-diMethylethyl)-5-nitro-](/CAS/GIF/873055-57-3.gif)
873055-57-3
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![2,4-DI(TERT-BUTYL)-6-NITROPHENOL](/StructureFile/ChemBookStructure1/GIF/CB4127431.gif)
20039-94-5
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