Penicillin G potassium salt synthesis
- Product Name:Penicillin G potassium salt
- CAS Number:113-98-4
- Molecular formula:C16H17KN2O4S
- Molecular Weight:372.48
61-33-6
245 suppliers
$161.00/y0001889
113-98-4
447 suppliers
$7.00/250mg
Yield:113-98-4 94.5%
Reaction Conditions:
with potassium carbonate in acetic acid butyl ester;water;butan-1-ol at 45 - 48;Product distribution / selectivity;
Steps:
2
A series of experiments was carried out in which to 1000 ml of an activated- carbon-treated extract containing approximately 100,000 Oxford Units Penicillin G per ml in n-butylacetate, a 50% (w/w) solution of K2CO3 in water was added such that the mixture contained approximately 1.0 mole-equivalent of potassium with regard to penicillin G. The resulting mixture was heated under vacuum using a rotary film evaporator (bath 45-489C) whereby a certain quantity of the mixture was evaporated - see Table 1 for the amount for each experiment. Subsequently, methanol was added to the residue and the mixture was agitated during 1 h at 25^. The suspension was filtered and the wet cake was washed with 70 ml n-butylacetate after which the wet cake was dried.Table 1 : cr stallization of Pen G K in n-but lacetate + addition of methanol to the residue
References:
WO2007/63107,2007,A1 Location in patent:Page/Page column 7-8
![4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- (2S,5R,6R)-, 2-propenyl ester (9CI)](/CAS/20200611/GIF/80127-23-7.gif)
80127-23-7
0 suppliers
inquiry
113-98-4
447 suppliers
$7.00/250mg