Pamoic acid synthesis
- Product Name:Pamoic acid
- CAS Number:130-85-8
- Molecular formula:C23H16O6
- Molecular Weight:388.37
Yield:-
Reaction Conditions:
with sodium hydroxide
Steps:
Pamoic acid may be prepared by condensing commercially available 3 -hydroxy-2 -naphthoic acid (Acros Organics, Fairlawn, NJ) with formaldehyde or paraformaldehyde in the presence of sodium hydroxide (Strohbach, 1901, Chem. Ber. 34:4148; Hosaeus, 1892, Chem. Ber.25:3215; Brass, 1928, Chem. Ber. 61 :1001), as shown in Scheme I.
References:
TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION;DUKE UNIVERSITY;RESEARCH TRIANGLE INSTITUTE;ABOOD, Mary, E.;ZHAO, Pingwei;BARAK, Lawrence, S.;SELTZMAN, Herbert, H. WO2011/11235, 2011, A1 Location in patent:Page/Page column 18
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