p-Tolyl isocyanate synthesis
- Product Name:p-Tolyl isocyanate
- CAS Number:622-58-2
- Molecular formula:C8H7NO
- Molecular Weight:133.15
Yield:622-58-2 90%
Reaction Conditions:
in chloroform at 20; for 2 h;Cooling with ice;
Steps:
General methods for aryl isocyanate (2a-h)
General procedure: To a solution of bis(trichloromethyl) carbonate in CHCl3 was added dropwisearomatic amines in CHCl3 in an ice bath. When the addition was finished, thereaction mixture was stirred at room temperature for 1-8 h and then heated atreflux until the reaction solution clarified. After the solvent was evaporatedunder atmospheric pressure, the residual liquid could be evaporated underreduced pressure.
References:
Zheng, Zhonghui;Du, Deping;Cao, Lili;Liu, Jun;Chen, Xiaofang [Journal of Antibiotics,2016,vol. 69,# 11,p. 811 - 817]
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