Nebivolol Impurity 3 synthesis
1synthesis methods
- Product Name:Nebivolol Impurity 3
- CAS Number:1029684-20-5
- Molecular formula:C18H20FNO2
- Molecular Weight:301.36
![(R)-6-Fluoro-2-[(R)-2-oxiranyl]chromane](/CAS/20181212/GIF/197706-50-6.gif)
Yield:> 99 % ee
Reaction Conditions:
in n-heptane;toluene at 80; for 4 h;Product distribution / selectivity;
Steps:
5.B
the filtrate was concentrated by rotary evaporation and the heptane/toluene 9/1 (10 ml) and benzylamine (2.48 g) were added to the residue. The mixture was heated to 8O0C and after 4 h was allowed to warm to rt and the solid was collected by vacuum filtration to give the title benzylamino-alcohol as a white powder (0.94 g, HPLC purity: 99 %, e.e. > 99 %).NMR: δH(400 MHz; CDCl3) 7.39-7,27 (5H, m, Ar), 6.82-6.67 (3H, m, Ar), 4.0-3.76 (4H, m), 3.97-2.7 (4H, m), 2.0-1.8 (2H, m).
References:
WO2008/64826,2008,A1 Location in patent:Page/Page column 24