N1-(5-CHLORO-4-FLUORO-2-NITROPHENYL)ACETAMIDE synthesis
- Product Name:N1-(5-CHLORO-4-FLUORO-2-NITROPHENYL)ACETAMIDE
- CAS Number:81962-58-5
- Molecular formula:C8H6ClFN2O3
- Molecular Weight:232.6
877-90-7
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81962-58-5
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$10.00/250mg
Yield:81962-58-5 90%
Reaction Conditions:
with sulfuric acid;HNO3 at -4 - 20; for 0.666667 h;
Steps:
2 4.5.2. Synthesis of N-(2-nitro-4-fluoro-5-chlorophenyl)acetamide (3)
To a cold (-4 °C) mixture of 70% nitric acid (18.2 mL) and concentrated sulfuric acid (18.2 mL), compound 2 (10 g, 0.05 mol) was added in small portions.
The mixture was stirred at 0 °C for 10 min and then at room temperature for further 30 min.
The acidic solution was then poured into ice-cold water.
The precipitates obtained were filtered off and washed thoroughly with ice-cold water.
Pale yellow colored desired product 3 was obtained (yield 90%, m.p. 106-108 °C).
References:
Patel, Saloni B.;Patel, Bhumika D.;Pannecouque, Christophe;Bhatt, Hardik G. [European Journal of Medicinal Chemistry,2016,vol. 117,p. 230 - 240]
877-90-7
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$14.00/1g
7697-37-2
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81962-58-5
24 suppliers
$10.00/250mg
367-21-5
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$5.00/25g
81962-58-5
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$10.00/250mg
367-21-5
510 suppliers
$5.00/25g
108-24-7
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81962-58-5
24 suppliers
$10.00/250mg