N-Methylparoxetine synthesis
- Product Name:N-Methylparoxetine
- CAS Number:110429-36-2
- Molecular formula:C20H22FNO3
- Molecular Weight:343.39
533-31-3
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![trans-(-)-4-(4-Fluorophenyl)-1-methyl-3-[(4-toluenesulfonyloxy)methyl]piperidine](/CAS/GIF/317323-77-6.gif)
317323-77-6
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110429-36-2
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Yield:-
Reaction Conditions:
with potassium tert-butylate in N,N-dimethyl acetamide at 55 - 60; for 2 h;
Steps:
2
Example 2:; Preparation of iV-methylparoxetine, compound of formula V (wherein R' is methyl).; To a stirred solution of sesamol (27.5g) in AζN-dimethylacetamide (150ml) was added potassium tertiary butoxide (18.5g), followed by compound of formula IV (wherein R' is methyl and R" is jp-tolyl) (50g). The mixture was heated for 2hrs under stirring at 55 to 60 C, cooled to 10-150C, and quenched with aqueous sodium hydroxide. The product was filtered, washed with water and dried till constant weight to obtain N-methylparoxetine as a white solid, purity >99.0% by HPLC.
References:
WO2007/15262,2007,A2 Location in patent:Page/Page column 16
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61869-08-7
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110429-36-2
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110429-36-2
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110429-36-2
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110429-36-2
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