ChemicalBook CAS DataBase List N-Isopropylacetamide

N-Isopropylacetamide synthesis

10synthesis methods

Product Name:N-Isopropylacetamide
CAS Number:1118-69-0
Molecular formula:C5H11NO
Molecular Weight:101.15

75-31-0 Synthesis

75-31-0
429 suppliers
$14.00/25mL

75-36-5 Synthesis

75-36-5
583 suppliers
$17.92/100G

1118-69-0
95 suppliers
$59.00/25g

Yield:1118-69-0 92%

Reaction Conditions:

with hydroxyapatite supported copper(I) oxide in acetonitrile at 50; for 0.1 h;

Steps:

General procedure for N-acetylation of amines usingHAP-Cu2O
General procedure: To a mixture of amine (1 mmol), acetyl chloride (1 mmol)in acetonitrile (5 mL) were added hydroxyapatite -Cu2O(0.1 g) under air atmosphere. The reaction mixture wasrefluxed at 50 °C for an appropriate time. The progress ofthe reaction was monitored through TLC. Upon completionof the reaction, the reaction mixture was cooled toroom temperature and filtered. The residue was washedwith water followed by EtOAc (3 × 10 mL). The productwas obtained after the removal of solvent under reducedpressure followed by crystallization from pet ether orEtOAc:pet ether or passing through column of silica andelution with EtOAc:pet ether.

References:

Gupta, Manjulla;Gupta, Monika [Journal of the Iranian Chemical Society,2016,vol. 13,# 2,p. 231 - 241]

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