Yield:1240287-62-0 53%

Reaction Conditions:

Stage #1: N-isopropyl-3-bromo-4-methylbenzenesulfonamidewith sodium hydride in N,N-dimethyl-formamide at 20; for 0.0833333 h;
Stage #2: methyl iodide in N,N-dimethyl-formamide at 20; for 40 h;

References:

Crosignani, Stefano;Prêtre, Adeline;Jorand-Lebrun, Catherine;Fraboulet, Ga?le;Seenisamy, Jeyaprakashnarayanan;Augustine, John Kallikat;Missotten, Marc;Humbert, Yves;Cleva, Christophe;Abla, Nada;Daff, Hamina;Schott, Olivier;Schneider, Manfred;Burgat-Charvillon, Fabienne;Rivron, Delphine;Hamernig, Ingrid;Arrighi, Jean-Fran?ois;Gaudet, Marilène;Zimmerli, Simone C.;Juillard, Pierre;Johnson, Zoe [Journal of Medicinal Chemistry,2011,vol. 54,# 20,p. 7299 - 7317] Location in patent:supporting information; experimental part