N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID synthesis
- Product Name:N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID
- CAS Number:102507-13-1
- Molecular formula:C10H19NO5
- Molecular Weight:233.26
![Carbamic acid, [2-hydroxy-1-(hydroxymethyl)-2-methylpropyl]-, 1,1-](/CAS/20180808/GIF/182958-73-2.gif)
182958-73-2
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102507-13-1
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$43.00/100mg
Yield:102507-13-1 76%
Reaction Conditions:
with sodium dihydrogenphosphate in tetrahydrofuran at 0; for 4 h;
Steps:
1.2 Step 2: Preparation of (s)-2-tert-butoxyamido-3-methyl-3-hydroxybutyric acid
(s)-2-tert-butoxyamido-3-methyl-3-hydroxybutanol (20 g) was added to THF (50 mL). After adding saturated sodium dihydrogen phosphate solution (50 mL), the reaction was cooled to 0°C. Add bleach (6%, 350 mL) slowly. After 4 hours of reaction, slowly rise to room temperature. After TLC detects that the reaction is complete, it is quenched by adding sodium thiosulfate. Rotary evaporation to remove THF, then add dichloromethane (100mLX4) for extraction, dry and filter, concentrate to the crude reaction product, add n-hexane (100mL), beating and filtering to obtain pure product (s)-2-tert-butoxyamide -3-Methyl-3-hydroxybutyric acid (16 g, 76%).
References:
Zhejiang Kaipu Chemical Co., Ltd.;Luo Linfeng;Tan Xianghui;Yan Xiaodong;Shen Yipeng;Zhou Chen CN111909067, 2020, A Location in patent:Paragraph 0023-0025; 0028-0029
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473545-40-3
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102507-13-1
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$43.00/100mg
288159-36-4
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102507-13-1
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75-16-1
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$12.00/10ml
95715-85-8
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$5.00/1g
102507-13-1
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$43.00/100mg
2280-27-5
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$77.00/100mg
34619-03-9
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102507-13-1
134 suppliers
$43.00/100mg