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ChemicalBook CAS DataBase List N-Boc-N-methyl-(S)-2-allylglycine
136092-76-7

N-Boc-N-methyl-(S)-2-allylglycine synthesis

4synthesis methods
-

Yield:136092-76-7 5.38 g

Reaction Conditions:

Stage #1: (2S)-2-[(tert-butoxycarbonyl)amino]pent-4-enoic acidwith sodium hydride in tetrahydrofuran;mineral oil at 0; for 0.5 h;Inert atmosphere;
Stage #2: methyl iodide in tetrahydrofuran;mineral oil at 0 - 20;Inert atmosphere;

References:

Koike, Kota;Nagano, Masanobu;Ebihara, Masahiro;Hirayama, Tasuku;Tsuji, Mieko;Suga, Hiroaki;Nagasawa, Hideko [Journal of Medicinal Chemistry,2020,vol. 63,# 8,p. 4022 - 4046]

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