N-Boc-cis-4-Hydroxy-L-proline synthesis
- Product Name:N-Boc-cis-4-Hydroxy-L-proline
- CAS Number:87691-27-8
- Molecular formula:C10H17NO5
- Molecular Weight:231.25
84348-37-8
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$5.00/250mg
87691-27-8
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$6.00/250mg
Yield:87691-27-8 99.1%
Reaction Conditions:
with sodium tetrahydroborate in methanol at 0 - 5;
Steps:
3.b Preparation of product cis-F-1
The reducing agent (4.0 to 5.0 e.q.) was added to the solvent,Cold to a certain temperature,Add the substrate in batches to exotherm,HPLC monitoring reaction,Reaction is completed,The reaction solution was added to water,Cooling to 0 ~ 5C,With dilute hydrochloric acid pH 2 ~ 3, EA extraction(5X * 3). The combined organic phases were washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the crude product. The crude productThe product was crystallized from a mixed solvent of ethyl acetate and alkane.
References:
CN106543062,2017,A Location in patent:Paragraph 0021; 0024; 0027
24424-99-5
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618-27-9
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$9.00/250mg
87691-27-8
231 suppliers
$6.00/250mg
168264-25-3
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87691-27-8
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$6.00/250mg
13726-69-7
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$5.00/1g
87691-27-8
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$6.00/250mg
![tert-butyl 3-oxo-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate](/CAS/GIF/87250-97-3.gif)
87250-97-3
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87691-27-8
231 suppliers
$6.00/250mg