ChemicalBook CAS DataBase List N-BENZYL-4-METHOXYANILINE

N-BENZYL-4-METHOXYANILINE synthesis

15synthesis methods

Product Name:N-BENZYL-4-METHOXYANILINE
CAS Number:17377-95-6
Molecular formula:C14H15NO
Molecular Weight:213.27

104-92-7 Synthesis

104-92-7
428 suppliers
$10.00/10g

100-46-9 Synthesis

100-46-9
483 suppliers
$5.00/5 g

17377-95-6
81 suppliers
$58.00/5g

Yield: 98%

Reaction Conditions:

with copper(I) oxide;C₁₈H₁₈Br₂N₂O₂;potassium hydroxide in dimethyl sulfoxide at 80; for 12 h;Inert atmosphere;Schlenk technique;Reagent/catalyst;Solvent;Temperature;

Steps:

29 Example 29
Example 29 Coupling Reaction of 4-bromoanisole with Benzylamine. Copper catalyst (0.01 mmol), ligand (0.01 mmol) and base (1.5 mmol) were added into a 10 mL of Schlenk tube. The tube was evacuated and backfilled with argon (three times), and then 4-bromoanisole (1.0 mmol), benzylamine (1.5 mmol) and 1 mL of solvent were added. The reaction mixture was stirred well at 80°C. for 12 hours. After cooling, water and ethyl acetate were added and mixture was separated. The aqueous phase was extracted twice with ethyl acetate. The combined organic phase was dried over anhydrous sodium sulfate. After concentration, the residue was purified by column chromatography to give the product N-(4-methoxy)phenylbenzylamine .

References:

CE Pharm CO., LTD;Ma, Dawei;Zhou, Wei;Fan, Mengyang;Wu, Haibo;Yin, Junli;Xia, Shanghua US10500577, 2019, B2 Location in patent:Page/Page column 123

7472-54-0 Synthesis