N-(2-FLUORO-6-NITRO-PHENYL)-ACETAMIDE synthesis
- Product Name:N-(2-FLUORO-6-NITRO-PHENYL)-ACETAMIDE
- CAS Number:342-52-9
- Molecular formula:C8H7FN2O3
- Molecular Weight:198.15
Yield:342-52-9 90%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in dichloromethane at 20; for 24.25 h;
Steps:
1c.i
Step iN-(2-fluoro-6-nitrophenyl)acetamide A mixture of 2-Fluoro-6-nitroaniline (12.6g, 80.8 mmol) and DIPEA (13.5g, 1.3eq) in DCM (150 mL) was treated with acetyl chloride (8.2g, 1.3eq) dropwise over 15 mins and stirred at room temperature for 24 hrs. The reaction mixture was quenched by addition of H20, the organic layer was collected and the aqueous phase re-extracted with DCM, the combined organics were washed with dil. HCl(aq), brine, dried (phase separator) and concentrated in vacuo to afford a yellow solid (yield 15.6g, 90%). LCMS method A, (ES+) 199, RT = 1.33 min
References:
WO2011/29807,2011,A1 Location in patent:Page/Page column 36-37
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