METHYL QUINOLINE-6-CARBOXYLATE synthesis
- Product Name:METHYL QUINOLINE-6-CARBOXYLATE
- CAS Number:38896-30-9
- Molecular formula:C11H9NO2
- Molecular Weight:187.19
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Yield:38896-30-9 98%
Reaction Conditions:
with thionyl chloride at 0 - 50; for 12 h;
Steps:
7 Example 7: 6-(methoxycarbonyl)quinoline
6.0 mmol of thionyl chloride was slowly added to 2.0 mmol of 6-quinolinecarboxylic acid dissolved in 5 mL of methanol at 0 and the reaction mixture was stirred at 50 for 12 hours. 30 mL of saturated aqueous NaHCO3solution was added thereto, and the reaction was allowed to be completed. The reaction mixture was extracted with 30 mL of dichloromethane three times. The reaction mixture was dried over MgSO4, then a solid was filtered off, and an organic solvent was removed under reduced pressure 6-(methoxycarbonyl)quinoline as a white solid in 98 % yield.
References:
WO2015/160125,2015,A1 Location in patent:Paragraph 143-145
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