METHYL OROTATE synthesis
- Product Name:METHYL OROTATE
- CAS Number:6153-44-2
- Molecular formula:C6H6N2O4
- Molecular Weight:170.12
67-56-1
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65-86-1
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6153-44-2
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Yield: 92.9%
Reaction Conditions:
with thionyl chloride at 0 - 5; for 6 h;Reflux;
Steps:
9.1
In a 500 mL three-necked flask,Add orotic acid(15.6 g, 0.10 mol),Then 300 mL of anhydrous methanol was added,Stirring down to 0 ,Maintain the temperature 0 ~ 5 drop add thionyl chloride(10.9 mL, 0.15 mol),And the temperature was raised to reflux for 6 hours.Slightly cold,Vacuum drying solvent,Add 50 mL of anhydrous methanol to lift off.150 mL of methyl t-butyl ether was added,Stirred at room temperature for 1 hour,Filter,Methyl tert-butyl ether wash.dry,To obtain 15.8 g of compound 1,Yield 92.9%.
References:
Shandong Chuangxin Pharmaceutical Research And Development Co., Ltd.;Jiang Hong;Lv Chuantao;Ma Chonglei;Lin Hongjie;Hao Lianfeng;Liu Yongyong;Lu Jingjing CN106831607, 2017, A Location in patent:Paragraph 0047
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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6153-44-2
122 suppliers
$7.00/250mg
65-86-1
427 suppliers
$5.00/100mg
6153-44-2
122 suppliers
$7.00/250mg
6314-14-3
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$33.39/250mg
6153-44-2
122 suppliers
$7.00/250mg
