(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate synthesis
- Product Name:(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate
- CAS Number:114676-69-6
- Molecular formula:C11H19NO5
- Molecular Weight:245.27
24424-99-5
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114676-59-4
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$6.00/250mg
114676-69-6
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$6.00/1g
Yield:114676-69-6 100%
Reaction Conditions:
with dmap;triethylamine in water;acetone;
Steps:
1.4.2
[0347] To a solution of (2R,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride (4.4 g, 24.67 mmol) in Acetone and water (3:2, 30 mL) were added Et3N (6.8 mL , 49.28 mmol), DMAP (150 mg, 1.2 mmol). Then (Boc)20 (8.0 mL, 34.54 mmol) was added slowly and the reaction was stirred overnight. All the acetone was removed and diluted with EtOAc and washed with 0.5 N HC1, water, brine, dried and concentrated to yield 6.0 g of (2R,4R)-1- tert-butyl 2-methyl 4-hydroxypyrrolidine-l,2-dicarboxylate (quantitative).
References:
WO2011/130383,2011,A1 Location in patent:Page/Page column 104
135042-12-5
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74-88-4
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114676-69-6
185 suppliers
$6.00/1g
24424-99-5
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$13.50/25G
2584-71-6
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$6.00/1g
114676-69-6
185 suppliers
$6.00/1g
24424-99-5
858 suppliers
$13.50/25G
114676-47-0
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$95.00/250mg
114676-69-6
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$6.00/1g
67-56-1
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135042-12-5
194 suppliers
$6.00/1g
114676-69-6
185 suppliers
$6.00/1g