methyl 7-chloro-1H-indole-2-carboxylate synthesis
- Product Name:methyl 7-chloro-1H-indole-2-carboxylate
- CAS Number:940960-50-9
- Molecular formula:C10H8ClNO2
- Molecular Weight:209.63
67-56-1
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Yield:940960-50-9 93.31 %
Reaction Conditions:
with sulfuric acid at 70;Temperature;
Steps:
7-chloro-1-methylindole-2-carboxylic acid
Step-1: To mixture of 7-chloro-1H-indole-2-carboxylic acid (1 g, 5.112 mmol) in MeOH (20 mL) was added H2SO4 (0.50 g, 5.112 mmol). The resulting mixture was stirred at 70?C overnight. The resulting mixture was extracted with EtOAc. The combined organic layers were washed with brine, dried over anhydrous Na2SO4. This resulted in methyl 7-chloro-1H-indole-2-carboxylate (1 g, 93.31%) as a yellow solid. MS m/z 208.0 [M-1]-
References:
WO2023/287704,2023,A1 Location in patent:Page/Page column 33-34; 41
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