methyl 5-iodofuran-2-carboxylate synthesis
- Product Name:methyl 5-iodofuran-2-carboxylate
- CAS Number:2527-98-2
- Molecular formula:C6H5IO3
- Molecular Weight:252.01
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Yield:2527-98-2 92%
Reaction Conditions:
with sulfuric acid at 100; for 24 h;
Steps:
5 Example 5
Esterification reaction: 5.95g (25mmol) compound a was dissolved in 200ml of methanol, 6ml of concentrated sulfuric acid with a mass concentration of 98%, and the heat preservation was refluxed at 100 °C for 24h. TCL point plate inspection, reduced pressure concentration to remove solvent, add 200ml of ice water to the remaining reaction mixture, and adjust the pH with saturated sodium carbonate solution to 7 ~ 8, after ethyl acetate extraction, and then washed with saturated brine, drying and concentration to give compound b 5.78g (23mmol), yield of 92%.
References:
CN113979974,2022,A Location in patent:Paragraph 0059-0060
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