ChemicalBook CAS DataBase List METHYL 5-BROMO-3-HYDROXYBENZOATE

METHYL 5-BROMO-3-HYDROXYBENZOATE synthesis

7synthesis methods

Product Name:METHYL 5-BROMO-3-HYDROXYBENZOATE
CAS Number:192810-12-1
Molecular formula:C8H7BrO3
Molecular Weight:231.04

67-56-1 Synthesis

67-56-1
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140472-69-1
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$19.00/250mg

192810-12-1
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$72.90/250mg

Yield:192810-12-1 97%

Reaction Conditions:

with acetyl chloride at 0 - 20;Inert atmosphere;

Steps:

Methyl 3-bromo-5-hydroxybenzoate
To a flask containing 3-bromo-5-hydroxybenzoic acid (2.0 g, 9.2 mmol) in anhydrous MeOH (10 mL) at 0°C under N₂ was added AcCl (912 μ,, 12.9 mmol). The reaction mixture was allowed to warm to room temperature overnight. The mixture was diluted with EA and washed with NaHC0₃. The organic layers were dried and concentrated to provide 2.1g (97%) of methyl 3-bromo-5-hydroxybenzoate as a white solid. LCMS-ESI (m/z) calculated for C₈H₇Br0₃: 231.04; found 232.9 [M+H]⁺, t_R = 3.06 min.

References:

RECEPTOS, INC.;MARTINBOROUGH, Esther;BOEHM, Marcus, F.;YEAGER, Adam, Richard;TAMIYA, Junko;HUANG, Liming;BRAHMACHARY, Enugurthi;MOORJANI, Manisha;TIMONY, Gregg, Alan;BROOKS, Jennifer, L.;PEACH, Robert;SCOTT, Fiona, Lorraine;HANSON, Michael, Allen WO2015/66515, 2015, A1 Location in patent:Page/Page column 105

FullText

706791-83-5 Synthesis