methyl 4-sulphamoylbenzoate synthesis
- Product Name:methyl 4-sulphamoylbenzoate
- CAS Number:22808-73-7
- Molecular formula:C8H9NO4S
- Molecular Weight:215.23
67-56-1
773 suppliers
$9.00/25ml
138-41-0
322 suppliers
$11.00/25g
22808-73-7
43 suppliers
$96.00/100mg
Yield:22808-73-7 95%
Reaction Conditions:
with sulfuric acid for 8 h;Reflux;
Steps:
2 4.3.1 Synthetic procedure of methyl 4-sulfamoylbenzoate (6)
Commercially available, 73 4-sulfamoylbenzoic acid 5 (10mmol) was refluxed in dried 74 methanol with a catalytic amount of 75 conc. H2SO4 acid for 8h. After completion of the reaction, the mixture was poured into ice cold water and obtained precipitate was filtered and dried to give 11 methyl 4-sulfamoylbenzoate 6. 4.3.2 11 Methyl 4-sulfamoylbenzoate (6) (0035) White crystalline solid; yield 95%; mp: 148-150°C; 1H NMR (DMSO-d6,400MHz):δ 3.87 (s, 3H, OCH3), 7.55 (s, 2H, NH2), 7.94 (d, 2H, Ar, J=8.4Hz), 8.12 (d, 2H, Ar, J=8.4Hz); LC-MS: m/z; 216 (M+1).
References:
Mishra, Chandra Bhushan;Kumari, Shikha;Angeli, Andrea;Bua, Silvia;Buonanno, Martina;Monti, Simona Maria;Tiwari, Manisha;Supuran, Claudiu T. [European Journal of Medicinal Chemistry,2018,vol. 156,p. 430 - 443]
138-41-0
322 suppliers
$11.00/25g
18107-18-1
215 suppliers
$33.00/5g
22808-73-7
43 suppliers
$96.00/100mg
69812-51-7
117 suppliers
$39.00/1g
22808-73-7
43 suppliers
$96.00/100mg
138-41-0
322 suppliers
$11.00/25g
22808-73-7
43 suppliers
$96.00/100mg
70-55-3
585 suppliers
$6.00/100g
22808-73-7
43 suppliers
$96.00/100mg