ChemicalBook CAS DataBase List 4′-Methylbiphenyl-2-carboxylic acid methyl ester

4′-Methylbiphenyl-2-carboxylic acid methyl ester synthesis

11synthesis methods

Product Name:4′-Methylbiphenyl-2-carboxylic acid methyl ester
CAS Number:114772-34-8
Molecular formula:C15H14O2
Molecular Weight:226.27

67-56-1 Synthesis

67-56-1
755 suppliers
$7.29/5ml-f

7148-03-0
225 suppliers
$10.00/1g

4′-Methylbiphenyl-2-carboxylic acid methyl ester

114772-34-8
299 suppliers
$12.00/1g

Yield:114772-34-8 98.05%

Reaction Conditions:

with dmap;dicyclohexyl-carbodiimide at 25; for 3 h;Large scale;Temperature;

Steps:

1.2 preparation of 4'-methylbiphenyl-2-carboxylic acid methyl ester
To the kettle was added 5.30 kg4 & ' -methyl-2-carboxylic acid biphenyl,Anhydrous methanol 10. 60 kg,5. 83 kg DCC,0. 09 kg DMAP,25 ° C reaction for 3 hours,After filtration, the filtrate into another reactor, adding 50. 00kg of water, stirring crystallization, and then centrifuged, washed to neutral, 40 ° C vacuum drying 24 hours to get 5. 54kg4 '- methyl -2-- Formate biphenyl,Melting point 55 ~ 57 ° C, yield 98. 05%, purity 99. 06%.

References:

weite hunan pharmaceutical co ltd;He, liang;Luo, hui;Mo, wei CN105399627, 2016, A Location in patent:Paragraph 0056; 0057

FullText