METHYL (4-CYANOPHENYL)ACETATE synthesis
- Product Name:METHYL (4-CYANOPHENYL)ACETATE
- CAS Number:52798-01-3
- Molecular formula:C10H9NO2
- Molecular Weight:175.18
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Yield:52798-01-3 100%
Reaction Conditions:
with thionyl chloride for 12 h;Cooling with ice;
Steps:
4 Synthesis of methyl (4-cyanophenyl) acetate
General procedure: To an ice-cold solution of 4- cyanophenyl acetic acid (1 eq) in MeOH was added 1.5 eq of thionyl chloride dropwise and stirred for 12 hr. After completion of the reaction the methanol was evaporated and the reaction quenched slowly by adding saturated sodium bicarbonate solution and extracted three times with ethyl acetate, the organic extracts were combined and dried over anhydrous sodium sulfate and concentrated in vacuo. The residue was purified using flash chromatography using a hexane/ethyl acetate gradient to yield methyl (4-cyanophenyl) acetate as white solid in quantitative yield.
References:
WO2020/6508,2020,A1 Location in patent:Paragraph 0143; 0149
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