Methyl 4-bromo-2-chloronicotinate synthesis
- Product Name:Methyl 4-bromo-2-chloronicotinate
- CAS Number:1064678-14-3
- Molecular formula:C7H5BrClNO2
- Molecular Weight:250.48
73583-37-6
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$9.00/1g
79-22-1
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$38.00/1000g
1064678-14-3
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$96.90/1g
Yield: 96%
Reaction Conditions:
Stage #1:2-chloro-4-bromopyridine with lithium diisopropyl amide in tetrahydrofuran at -85 - -80; for 0.5 h;
Stage #2:methyl chloroformate in tetrahydrofuran at -80; for 0.833333 h;
References:
Gibson, Christoph;Schnatbaum, Karsten;Pfeifer, Jochen R.;Locardi, Elsa;Paschke, Matthias;Reimer, Ulf;Richter, Uwe;Scharn, Dirk;Faussner, Alexander;Tradler, Thomas [Journal of Medicinal Chemistry,2009,vol. 52,# 14,p. 4370 - 4379] Location in patent:supporting information; experimental part