Methyl-4-amino-3-fluorobenzoate synthesis
- Product Name:Methyl-4-amino-3-fluorobenzoate
- CAS Number:185629-32-7
- Molecular formula:C8H8FNO2
- Molecular Weight:169.15
185629-31-6
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185629-32-7
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$6.00/1g
Yield: 99%
Reaction Conditions:
with palladium on activated charcoal;hydrogen in ethanol;ethyl acetate at 20; under 760.051 Torr; for 16 h;
Steps:
135 Methyl 4-amino-3-fluorobenzoate
A mixture of methyl 3-fluoro-4-nitrobenzoate (2.50 g,12.5 mmol) and Pd/C (300 mg, 10 wt%) in 1:1 EtOAc/EtOH (40 mL) was stirred at rt for 16h under 1 atm of H2. The mixture was filtered through Celite and concentrated to give the titlecompound (2.1 g, 99%) as a beige solid. MS (ES+) C8H8FNO2 requires: 169, found: 170[M+Hj
References:
TESARO, INC.;JONES, Philip;CZAKO, Barbara;BURKE, Jason P.;CROSS, Jason;LEONARD, Paul Graham WO2018/81276, 2018, A1 Location in patent:Page/Page column 154
67-56-1
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455-87-8
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185629-32-7
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$6.00/1g
185629-31-6
165 suppliers
$5.00/250mg
5081-36-7
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403-21-4
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185629-32-7
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369-25-5
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185629-32-7
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$6.00/1g
403-21-4
255 suppliers
$6.00/1g
185629-32-7
105 suppliers
$6.00/1g