methyl 3-bromo-5-fluoro-2-methylbenzoate synthesis
- Product Name:methyl 3-bromo-5-fluoro-2-methylbenzoate
- CAS Number:1187318-53-1
- Molecular formula:C9H8BrFO2
- Molecular Weight:247.06
175278-29-2
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1187318-53-1
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Yield: 22 g
Reaction Conditions:
with N-Bromosuccinimide;sulfuric acid at 0 - 20; for 19 h;
Steps:
3.2 Step 2: Synthesis of Compound I-16C
Compound I-16B (15 g, 90 mmol) was added to a solution of concentrated sulfuric acid (200 mL).The ice bath was cooled to below 5 degrees Celsius and then NBS (17.8 g, 100 mmol) was added portionwise. The resulting mixture was stirred at 0 ° C for 3 hours, then at room temperature and stirred for 16 hours.Then slowly pour the mixture into ice water (2L).It was extracted with EtOAc (500 mL x 3).The combined organic layers were washed with water and brine.Drying and concentration gave Compound I-16C (22 g).
References:
Guangzhou Dankang Pharmaceutical Biological Co., Ltd.;Xu Yong;Huang Lu;Lin Dang;Hu Hai CN110092745, 2019, A Location in patent:Paragraph 0126-0128; 0132; 0133
1187318-52-0
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74-88-4
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67-56-1
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1187318-52-0
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1187318-53-1
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33184-16-6
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1187318-53-1
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850462-64-5
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1187318-53-1
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