METHYL 2-METHYL-3-(PYRROLIDIN-1-YL)PROPANOATE synthesis
- Product Name:METHYL 2-METHYL-3-(PYRROLIDIN-1-YL)PROPANOATE
- CAS Number:4151-03-5
- Molecular formula:C9H17NO2
- Molecular Weight:171.24
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Yield:4151-03-5 2002.5 g
Reaction Conditions:
at 50; for 26.5 h;Large scale;
Steps:
Preparative Example 7 (PE-7): Preparation of intermediate ECF cell feed methyl 2- methyl-3-pyrrolidino-propanoate.
Pyrrolidine (871.3 grams, 12.25mol) and methanol (332 grams) were charged to a 3 neck, 3 liter round bottom flask equipped with an overhead stirrer, thermocouple, pressure equalizing addition funnel, and cold water condenser. Methyl methacrylate (1226.8 grams, 12.25mol) was added over the course of 2.5 hours and held at 50 °C for 24 hours. The methanol and unreacted materials were removed by single plating under reduced pressure at 45 °C to afford 2002.5 grams of product with a purity of 96.6%. This material was fed to the ECF cell without further purification.
References:
WO2016/64585,2016,A1 Location in patent:Page/Page column 32