Methyl 2-cyano-2-(3-tetrahydrothienylidene)acetate synthesis
1synthesis methods
- Product Name:Methyl 2-cyano-2-(3-tetrahydrothienylidene)acetate
- CAS Number:40548-04-7
- Molecular formula:C8H9NO2S
- Molecular Weight:183.23
Yield:-
Reaction Conditions:
with ammonium acetate in methanol at 23 - 26;
Steps:
1.1; 2.1; 3.1 Example 1
(1) 20g of tetrahydrothiophene 3-ketoneMethyl cyanoacetate 22gAnd the catalyst ammonium acetate 0.2g dissolved in 60gIn methanol,Mechanical stirring,Reaction at 2326°C for 68hCool to -5 ~ 0 °C for 2 ~ 3h,To analyze the solids,It was filtered to dryness to give a white solid A.Dry to dry at 45 °C,Dry weight 31g;
References:
CN107739366,2018,A Location in patent:Paragraph 0019; 0020; 0023; 0024; 0027; 0028