Methyl 2-aMino-2-(3-chlorophenyl)acetate synthesis
1synthesis methods
- Product Name:Methyl 2-aMino-2-(3-chlorophenyl)acetate
- CAS Number:532987-11-4
- Molecular formula:C9H10ClNO2
- Molecular Weight:199.63
Yield:-
Reaction Conditions:
with dichloro sulfoxide at 0 - 20; for 18.5 h;
Steps:
15
To amino(3-chlorophenyl)acetic acid (5.Og; 26.95mmol) suspended in methanol (30ml) and stirred at ice-bath temperature under argon was added dropwise thionyl chloride (30ml) over 30min. After stirring for a further 2h at 50C and at room temperature for 16h, the reaction solution was evaporated under reduced pressure. Trituration of the residue with diethylether afforded the title compound as a ca. 1 :1 mixture with amino(3- chlorophenyl)acetic acid (6.16g).
References:
WO2007/104775,2007,A1 Location in patent:Page/Page column 39-40