Methyl 1-acetyl-2-oxoindoline-6-carboxylate synthesis
- Product Name:Methyl 1-acetyl-2-oxoindoline-6-carboxylate
- CAS Number:676326-36-6
- Molecular formula:C12H11NO4
- Molecular Weight:233.22
108-24-7
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Yield: 88.5%
Reaction Conditions:
at 130; for 3 h;Large scale;Temperature;
Steps:
1.1; 2.1; 3.1 (1) Synthesis of methyl 1-acetyl-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
Add 42.2L of acetic anhydride into a 60L reaction kettle, add 4.04kg methyl 2-oxo-2,3-dihydro-1H-indole-6-carboxylate with stirring, heat to 130°C, and react for 3h. Stop heating, the internal temperature drops to 46°C, and crystals are precipitated. Continue to cool down to 0-10, stir and crystallize for 2h, after suction filtration, the filter cake was washed twice with 15L petroleum ether, then washed once with 12L ice methanol (0-5°C), and dried. The product obtained is 4.36 kg, with a yield of 88.5% and a purity of 87.62%.
References:
Chifeng Jingfang Pharmaceutical Development Co., Ltd.;Zhang Lihua;Wang Dongmei;Zhang Xiaoran;Meng Qingbin;Sheng Li CN111848486, 2020, A Location in patent:Paragraph 0021; 0040-0042; 0049-0051; 0058-0060
14192-26-8
382 suppliers
$10.00/250mg
676326-36-6
91 suppliers
inquiry