LY 2784544 synthesis
- Product Name:LY 2784544
- CAS Number:1229236-86-5
- Molecular formula:C23H25ClFN7O
- Molecular Weight:469.94
![6-chloro-3-(4-chloro-2-fluorobenzyl)-2-Methyl-8-(Morpholin-4-ylMethyl)iMidazo[1,2-b]pyridazine](/CAS/20130318/GIF/CB92611133.gif)
1229236-85-4
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1229236-86-5
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Yield:-
Steps:
Multi-step reaction with 2 steps
1.1: tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium hydroxide / 5,5-dimethyl-1,3-cyclohexadiene; water / 40 h / Inert atmosphere; Reflux; Large scale reaction
2.1: trifluoroacetic acid / water / 7 h / 95 - 100 °C / Large scale reaction
2.2: 8 h / 60 °C / pH 10 - 11
References:
Mitchell, David;Cole, Kevin P.;Pollock, Patrick M.;Coppert, David M.;Burkholder, Timothy P.;Clayton, Joshua R. [Organic Process Research and Development,2012,vol. 16,# 1,p. 70 - 81]
1229236-79-6
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1229236-86-5
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$54.00/1mg
![(4-Chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)-imidazo[1,2-b]pyridazin-3-yl)met](/CAS/GIF/1229236-83-2.gif)
1229236-83-2
25 suppliers
$182.00/100mg
1229236-86-5
158 suppliers
$54.00/1mg
![(4-chloro-2-fluorophenyl)(6-chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)methanon](/CAS/20180629/GIF/1229236-80-9.gif)
1229236-80-9
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1229236-86-5
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175711-83-8
151 suppliers
$8.00/1g
1229236-86-5
158 suppliers
$54.00/1mg