L-(-)-Ephedrine synthesis
- Product Name:L-(-)-Ephedrine
- CAS Number:492-41-1
- Molecular formula:C9H13NO
- Molecular Weight:151.21
Yield:-
Reaction Conditions:
Pd(OH)2 in methanol
Steps:
3 Example 3
Example 3 L-erythro-(1R,2S)-2-amino-1-phenylpropan-1-ol A mixture of L-(R) -phenylacetylcarbinol (purity 79.1%; 4.75 g, 25.0 mmol), benzylamine (2.68 g, 25 mmol), 20% Pd(OH)2(1.00 g) and methanol (47 ml) was stirred for 6 hours at 50°C under hydrogen atmosphere (5 kg/cm2). The reaction mixture was filtered and the residue was washed with methanol. The filtrate and the washed liquor were combined and concentrated under reduced pressure to obtain crude L-erythro-(1R,2S)-2-amino-1-phenylpropan-1-ol (5.67 g). Erythro:threo = 88.3:11.7.
References:
NAGASE & COMPANY, LTD. EP1142864, 2001, A1
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