Ivabradine Impurity 1 Hydrochloride synthesis
- Product Name:Ivabradine Impurity 1 Hydrochloride
- CAS Number:85175-52-6
- Molecular formula:C16H25ClN2O3
- Molecular Weight:328.83
![2H-3-Benzazepin-2-one, 1,3-dihydro-7,8-dimethoxy-3-[3-[methyl(phenylmethyl)amino]propyl]-](/CAS/20210305/GIF/96254-71-6.gif)
96254-71-6
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85175-52-6
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Yield: 87%
Steps:
I N-[3-(7,8-Dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one-3-yl)-propyl]-methylamine hydrochloride
EXAMPLE I N-[3-(7,8-Dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one-3-yl)-propyl]-methylamine hydrochloride This compound was prepared analogous to Example B by catalytic hydrogenation of 1-[7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on -3-yl]-3-(N-benzyl-methylamino)-propane. Yield: 87% of theory. Melting point: 110° C. (decomp.).
References:
Dr. Karl Thomae Gesellschaft mit beschrankter Haftung US4490369, 1984, A
85175-65-1
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85175-52-6
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