Isosorbide 5-mononitrate synthesis
- Product Name:Isosorbide 5-mononitrate
- CAS Number:16051-77-7
- Molecular formula:C6H9NO6
- Molecular Weight:191.14
39698-15-2
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16051-77-7
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Yield:16051-77-7 89%
Reaction Conditions:
with potassium carbonate in methanol;water;
Steps:
7 EXAMPLE 7
400 mg (1.7 mmol) 5-O-acetyl-isosorbide-2-nitrate is added to 10 ml methanol and 50 mg potassium carbonate and the mixture is stirred for 12 hours at room temperature. Subsequently the solvent is removed, the residue is taken up in 2 ml water and extracted four times with 10 ml ethyl acetate each time. The solvent is removed from the combined organic phase and the residue is dried in a high vacuum. Yield: 300 mg (1.56 mmol) isosorbide-2-nitrate (89%) colourless crystalline substance m.p. 52°-53° C.
References:
US5614643,1997,A
652-67-5
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16051-77-7
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87-33-2
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16051-77-7
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65940-93-4
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16051-77-7
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