Ibrutinib D5 synthesis
- Product Name:Ibrutinib D5
- CAS Number:1553977-17-5
- Molecular formula:C25H24N6O2
- Molecular Weight:440.51
![(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine](/CAS/20150408/GIF/1276110-38-3.gif)
1276110-38-3
55 suppliers
$18.00/100mg
1553977-17-5
52 suppliers
$104.00/500μg
Yield:-
Steps:
Multi-step reaction with 6 steps
1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 6 h / 80 °C
2: triethylamine / dichloromethane / 10 h / 20 °C
3: ammonium formate; palladium on activated charcoal / ethanol / 2 h / 80 °C / Inert atmosphere
4: copper(II) sulfate / dichloromethane / 20 h / 20 - 30 °C
5: hydrogenchloride / water; ethanol / 3 h / 60 °C
6: triethylamine / tetrahydrofuran / 2 h / 0 - 10 °C
References:
Tierxi (Nanjing) Pharmaceutical Research And Development Co., Ltd.;Song Huafeng;Hu Yongzhu;Liu Chun;Fan Gaojun CN109988175, 2019, A
146631-00-7
268 suppliers
$6.00/1g
1553977-17-5
52 suppliers
$104.00/500μg