H-LEU-SER-P-NITRO-PHE-NLE-ALA-LEU-OME TFA synthesis
- Product Name:H-LEU-SER-P-NITRO-PHE-NLE-ALA-LEU-OME TFA
- CAS Number:99764-63-3
- Molecular formula:C36H56F3N7O12
- Molecular Weight:835.88
281235-00-5
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99764-63-3
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Yield:-
Reaction Conditions:
with trifluoroacetic acid in 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;
Steps:
R.123 Reference Example 123
Reference Example 123 Methyl 4-(piperidin-4-yl-oxy)-benzoate. 266 mg (0.79 mmol) of methyl 4-(N-BOC-piperidin-4-yl-oxy)-benzoate (reference Example 124) was dissolved in 4 ml of DCM to which 4 ml of TFA was added and stirred 1 h at room temperature. The mixture was evaporated to dryness and purified by preparative HPLC with the mobile phase water/acetonitrile/0.1% TFA to give 217 mg of the TFA salt of the title compound. 1H NMR (CD3OD): d 7.97 (d, 2H), 7.06 (d, 2H), 4.78-4.85 (m, 1H), 3.86 (s, 3H), 3.19-3.44 (m, 4H), 2.14-2.23 (m, 2H), 2.00-2.08 (m, 2H). MS (ion spray) m/z 236 (M+H)+.
References:
US6541505,2003,B1
![Pentanoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-5-(methylamino)-5-oxo-, phenylmethyl ester, (4S)-](/CAS/20210305/GIF/56698-52-3.gif)
56698-52-3
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inquiry
99764-63-3
28 suppliers
$75.70/5MG