Ethyl 1-aminocyclopropanecarboxylate hydrochloride synthesis
- Product Name:Ethyl 1-aminocyclopropanecarboxylate hydrochloride
- CAS Number:42303-42-4
- Molecular formula:C6H12ClNO2
- Molecular Weight:165.62
64-17-5
745 suppliers
$10.00/50g
22059-21-8
458 suppliers
$14.00/1g
42303-42-4
166 suppliers
$6.00/1g
Yield:42303-42-4 100%
Reaction Conditions:
with thionyl chloride at 0; for 2 h;Reflux;Green chemistry;
Steps:
3 Preparation of compound of formula III
The compound of the formula II (500.0 g, 4.95 mol) was added to ethanol (10 L) at room temperature, and thionyl chloride(883.4g, 7.43 mol) was added dropwise at 0 °C, and the reaction mixture was heated to reflux and stirred for 2 h. The solution was cooled to room temperature, concentrated, and washed three times with THF (1L×3) to give the compound of formula III, 819.8 g, yield 100%.
References:
Nanjing Yaoshi Technology Co., Ltd.;Nanjing Furunkaide Bio-pharmaceutical Co., Ltd.;Shu Qingning;Wang Wei CN108863958, 2018, A Location in patent:Paragraph 0073; 0074; 0075; 0076
107259-05-2
61 suppliers
$60.00/100mg
42303-42-4
166 suppliers
$6.00/1g
72784-47-5
52 suppliers
$45.00/10mg
42303-42-4
166 suppliers
$6.00/1g
3697-66-3
118 suppliers
$16.00/250mg
42303-42-4
166 suppliers
$6.00/1g
1559-02-0
318 suppliers
$5.00/5g
42303-42-4
166 suppliers
$6.00/1g