Grazoprevir interMediate synthesis
- Product Name:Grazoprevir interMediate
- CAS Number:1350619-77-0
- Molecular formula:C8H12O
- Molecular Weight:124.18
1224174-07-5
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Yield:-
Steps:
Multi-step reaction with 4 steps
1.1: sodium t-butanolate / 2-methyltetrahydrofuran / 20 h / 0 - 78 °C / Inert atmosphere
2.1: 2-methyltetrahydrofuran; tetrahydrofuran / 3.5 h / 60 °C / Inert atmosphere
3.1: pyridine; pyridinium hydrobromide perbromide / hexane; acetonitrile / -5 - 5 °C
4.1: urea hydrogen peroxide adduct; trifluoroacetic anhydride / ethyl acetate / 19 h / 0 - 3 °C / Inert atmosphere
4.2: 0 - 25 °C / Inert atmosphere
References:
WO2015/57611,2015,A1
154820-95-8
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$637.00/25g
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