ChemicalBook CAS DataBase List Gapicomine

Gapicomine synthesis

8synthesis methods

Product Name:Gapicomine
CAS Number:1539-39-5
Molecular formula:C12H13N3
Molecular Weight:199.25

100-48-1 Synthesis

100-48-1
502 suppliers
$8.00/25g

1539-39-5
31 suppliers
$71.00/100mg

Yield: 92%

Reaction Conditions:

with sodium tetrahydroborate;La_0.5Ca_0.5CoO₃ in methanol at 40; under 760.051 Torr; for 0.333333 h;chemoselective reaction;

Steps:

General procedure for the reduction of nitriles into their correspondingsec-amines.
General procedure: To a stirring mixture of the appropriate nitrile (1 mmol) and nanosized La0.5Ca0.5CoO3 perovskite (1 mol%, 1.9 mg) in MeOH (5 ml) at 40C, NaBH4 (2 mmol, 0.08 g) was added portion wise. After the completion of the reaction which was monitored by TLC using CHCl3: MeOH (30:1) as eluent, the catalyst was centrifuged off and the solvent was evaporatedunder reduced pressure. To the resulting oily liquid, water (20 ml) was added and the mixture was extracted with CH2Cl2 (2 × 20 ml). The organic layer was dried over anhydrous Na2SO4 and the solvent was evaporated under reduced pressure to afford the pure products.

References:

Bavandi, Hossein;Shiri, Ali;Tavakkoli, Haman [Journal of the Chilean Chemical Society,2017,vol. 62,# 1,p. 3330 - 3334]

696-54-8 Synthesis