
FS SAAM-6C synthesis
- Product Name:FS SAAM-6C
- CAS Number:34455-22-6
- Molecular formula:C13H17F13N2O2S
- Molecular Weight:512.33
Yield:34455-22-6 68%
Reaction Conditions:
in toluene at 30 - 75; for 24 h;
Steps:
Add 2.08g (24mmol, 1.2eq.) of 3-dimethylaminopropylamine, 12mL toluene into a 50mL three-necked flask, assemble a reflux device, raise the temperature to 30-60°C, and add the compound dropwise with a constant pressure dropping funnel J: The ratio of compound J to dimethylaminopropylamine is 1:1.2-2. After the dropping is completed, the temperature is increased to 75° C., and the reaction is carried out for 24 hours. After the reaction, it was washed with saturated brine, extracted three times with dichloromethane, the organic layers were combined, dried over anhydrous sodium sulfate, and the solvent was removed by rotary evaporation to obtain a crude yellow solid product, which was recrystallized from ethanol to obtain a white solid K. A large amount of foam is generated during rotary steaming, and a small amount of ethanol can be added to defoam.
References:
CN111440097,2020,A Location in patent:Paragraph 0050