FMOC-4-AMINOBENZOIC ACID synthesis
- Product Name:FMOC-4-AMINOBENZOIC ACID
- CAS Number:185116-43-2
- Molecular formula:C22H17NO4
- Molecular Weight:359.37
28920-43-6
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185116-43-2
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Yield: 94%
Reaction Conditions:
for 24 h;Inert atmosphere;
Steps:
N--Fmoc--p--amino benzoic acid
p--Aminobenzoic acid (10 g, 73 mmol) was dissolved in dry NMP (50 ml) under an inert atmosphere followed by the dropwise addition of Fmoc--Cl (18.9 g, 73 mmol) in dry NMP (50 ml). After 24 hrs, the reaction mixture was poured slowly into 400 ml water. The colorless precipitate was collected by filtration, washed with water and dried in vacuum at 120 oC to give N-Fmoc--p--amino benzoic acid (24.8 g, 94%). mp: 215 oC (dec.) 1H--NMR: δ (300 MHz, DMSO-d6) 4.33 (t, 3J = 6.25 Hz, 1 H); 4.54 (d, 3J = 6.25 Hz, 2 H); 7.33--7.45 (m, 4 H); 7.57 (d, 3J = 7.35 Hz, 2 H); 7.76 (d, 3J = 7.35 Hz, 2 H); 7.89 (m, 4 H), 10.08 (s, 1H); 12.69 (s, 1H). 13C--NMR and DEPT: δ (300 MHz, DMSO--d6) 46.61 (+); 65.83 (--); 117.5 (+); 120.22 (+); 124.48; 125.14 (+); 127.17 (+); 127.74 (+); 130.48 (+); 140.86; 143.31; 143.74; 153.31; 167.03. IR ν (cm---1): 3344, 2970, 2887, 2660, 2544, 1709, 1673, 1610, 1592, 1526, 1511, 1411, 1311, 1282, 1221, 1052, 850, 736. RP--HPLC (min): 26.6 min. M (FD): m/z (%) = 359.1 (100); 360.1 (17.4); calc.[C22H17NO4] = 359.1
References:
Seyler, Helga;Kilbinger, Andreas [Tetrahedron Letters,2013,vol. 54,# 8,p. 753 - 756] Location in patent:supporting information
82911-69-1
642 suppliers
$7.00/25g
150-13-0
931 suppliers
$5.00/25g
185116-43-2
123 suppliers
$8.00/1g