ETHYL TRANS-3-(1-PYRROLIDINO)ACRYLATE synthesis
- Product Name:ETHYL TRANS-3-(1-PYRROLIDINO)ACRYLATE
- CAS Number:65651-80-1
- Molecular formula:C9H15NO2
- Molecular Weight:169.22
Yield:65651-80-1 99%
Reaction Conditions:
with water in neat (no solvent) at 20; for 0.166667 h;Sealed tube;Green chemistry;stereoselective reaction;Michael Addition;
Steps:
Ethyl (2E)-3-[Methyl(phenyl)amino]acrylate (3a); TypicalProcedure
General procedure: Ethyl propiolate (0.5 mmol) was slowly added with stirring to amixture of N-methylaniline (0.6 mmol) and distilled H2O (0.1mL) in a 2 mL vial, and the vial then sealed. The mixture washeated at 80 °C with stirring for 1 h. The reaction was thenquenched with sat. brine (0.5 mL), and the mixture was cooledto r.t. and extracted with EtOAc (3 × 1 mL) by pipette in thesame vial. The combined organic layers were dried (Na2SO4), filtered,and concentrated under reduced pressure. The residuewas purified by column chromatography [silica gel, PE-EtOAc(8:1)] to give a pale yellow oil
References:
Chen, Guang;Chen, Xiao Yun;Cheng, Xiaofang;Tang, Yaonan;Yuan, Shuxia;Zhang, Luming;Zhu, Baocheng [Synlett,2020,vol. 31,# 9,p. 878 - 882] Location in patent:supporting information
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