![119825-27-3](/StructureFile/ChemBookStructure22/GIF/CB2648990.gif)
ETHYL 6-FORMYLAMINO-5-METHOXYINDOLE-2-CARBOXYLATE synthesis
- Product Name:ETHYL 6-FORMYLAMINO-5-METHOXYINDOLE-2-CARBOXYLATE
- CAS Number:119825-27-3
- Molecular formula:C13H14N2O4
- Molecular Weight:262.26
![ETHYL PYRUVATE-3-FORMYLAMINO-4-METHOXYPHENYLHYDRAZONE](/CAS/GIF/107575-59-7.gif)
107575-59-7
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$405.00/50mg
![ETHYL 6-FORMYLAMINO-5-METHOXYINDOLE-2-CARBOXYLATE](/StructureFile/ChemBookStructure22/GIF/CB2648990.gif)
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Yield:119825-27-3 75.2%
Reaction Conditions:
with formic acid at 80;
Steps:
1.E; e
Ethyl 2-[(3-formylamino-4-memoxypheiiyl)hydrazono)propionate (6) (425.0 g, 1.53 mol) and 1530 mL of formic acid were placed in a 3-L, 3-neck flask equipped with a mechanical stirrer, a temperature probe, a condenser, and a heating mantle. The reaction mixture was stirred overnight at 80 °C.The reaction mixture was allowed to cool and 770 mL of ethanol was added. The bright-green slurry was cooled to 0 0C and stirred for two hours. The product was collected by filtration and washed with 700 mL of ethanol. The green-brown product was dried on the filter and then at 80 0C under house vacuum to afford 300.1 g (75.2%) of the title compound.; Following in step e, ethyl 2-[(3-formylamino-4-methoxyphenyl)hydrazono]- propionate (6) and formic acid were placed in a reaction vessel and stirred overnight at 80 0C. The reaction mixture was allowed to cool and ethanol was added. The bright-green slurry was cooled to 0 0C and stirred. The product was collected by vacuum filtration, washed with ethanol, dried on a filter and dried at 80 0C under vacuum to afford the desired indole, ethyl 6-fomiylamino-5-methoxy-lH-indole-2-carboxylate (7) via the Fischer Indole Synthesis.
References:
WO2006/102642,2006,A1 Location in patent:Page/Page column 9; 14; 1/6
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99-59-2
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$15.00/5mg
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149686-06-6
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$28.60/250mg
![ETHYL 6-FORMYLAMINO-5-METHOXYINDOLE-2-CARBOXYLATE](/StructureFile/ChemBookStructure22/GIF/CB2648990.gif)
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![2-METHOXY-5-AMINOFORMANILIDE](/CAS/GIF/78939-34-1.gif)
78939-34-1
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$85.00/100mg
![ETHYL 6-FORMYLAMINO-5-METHOXYINDOLE-2-CARBOXYLATE](/StructureFile/ChemBookStructure22/GIF/CB2648990.gif)
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![Propanoic-3,3,3-d3 acid, 2-[[3-(formylamino)-4-methoxyphenyl]hydrazono]-, ethyl ester (9CI)](/CAS/20211123/GIF/119825-26-2.gif)
119825-26-2
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![ETHYL 6-FORMYLAMINO-5-METHOXYINDOLE-2-CARBOXYLATE](/StructureFile/ChemBookStructure22/GIF/CB2648990.gif)
119825-27-3
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