Ethyl 5-hydroxy-2-benzofurancarboxylate synthesis

8synthesis methods

Product Name:Ethyl 5-hydroxy-2-benzofurancarboxylate
CAS Number:99370-68-0
Molecular formula:C11H10O4
Molecular Weight:206.19

5-METHOXYBENZOFURAN-2-CARBOXYLIC ACID, ETHYL ESTER

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Yield:99370-68-0 100%

Reaction Conditions:

with boron tribromide in dichloromethane at -60 - 0; for 2 h;

Steps:

85 Synthesis of Compound 4

The solution of BBr₃(40 g, 160.0 mmol) in DCM (100 mL) was added dropwise to the solution of compound 3 (9 g, 40.9 mmol) in DCM (300 mL) at -60° C. After that the reaction mixture was warmed slowly to 0° C. and stirred for another 1 h. The reaction mixture was quenched with EtOH (10 ml) slowly at -60° C. The reaction mixture was washed with water, brine, dried over Na₂SO₄, concentrated to give compound 4 (8.8 g, 100% yield).

References:

JP2015/214548,2015,A Location in patent:Paragraph 1416; 1418; 1419