ETHYL 5-(BROMOMETHYL)ISOXAZOLE-3-CARBOXYLATE synthesis

7synthesis methods

Product Name:ETHYL 5-(BROMOMETHYL)ISOXAZOLE-3-CARBOXYLATE
CAS Number:84654-29-5
Molecular formula:C7H8BrNO3
Molecular Weight:234.05

106-96-7 Synthesis

106-96-7
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$32.00/25g

14337-43-0 Synthesis

2-CHLORO-2-HYDROXYIMINOACETIC ACID ETHYL ESTER

14337-43-0
224 suppliers
$9.00/1g

ETHYL 5-(BROMOMETHYL)ISOXAZOLE-3-CARBOXYLATE

84654-29-5
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Yield:84654-29-5 87%

Reaction Conditions:

with Sodium hydrogenocarbonate in water monomer;ethyl acetate at 20; for 24 h;

Steps:

6.2

Method 2; A solution of ethyl 2-chloro-2-(hydroxyimino)acetate (1 1 g; 70.41 mmol) in ethyl acetate (60 mL) was added dropwise at room temperature to a mixture of 3-bromoprop-1-yne (15.2 mL; 141 mmol), sodium bicarbonate (11.95 g; 141 mmol), ethyl acetate (400 mL), and water (4 mL). The mixture was stirred at room temperature for 24 h and the solid was removed by filtration and washed with ethyl acetate. The filtrate was concentrated under reduced pressure and the residue was purified by flash chromatography on silica gel (eluent: 15 to 100% of dichloromethane in heptane) to give 14.38 g (87%) of ethyl 5- (bromomethyl)isoxazole-3-carboxylate as a white solid. ESI/APCI(+): 234 (M+H).¹H NMR (CDCI₃) 6.74 (s, 1 H); 4.50 (s, 2H); 4.45 (q, 2H); 1.42 (t, 3H).

References:

WO2010/142801,2010,A1 Location in patent:Page/Page column 148

123770-62-7 Synthesis