ETHYL 5-ACETYLISOXASOLE-3-CARBOXYLATE synthesis
- Product Name:ETHYL 5-ACETYLISOXASOLE-3-CARBOXYLATE
- CAS Number:104776-70-7
- Molecular formula:C8H9NO4
- Molecular Weight:183.16
78934-71-1
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104776-70-7
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Yield: 89%
Reaction Conditions:
with 2-iodoxybenzoic acid in ethyl acetate at 80; for 17 h;
Steps:
26.2 Step 2:
Step 2:
Preparation of ethyl 5-acetylisoxazole-3-carboxylate
To a solution of ethyl 5-(1-hydroxyethyl)isoxazole-3-carboxylate (5.0 g, 27.0 mmol) in ethyl acetate (50 mL) was added 2-iodoxybenzoic acid (22.7 g, 81.1 mmol).
After addition, the reaction mixture was heated to 80° C. and stirred for 17 h, then cooled to room temperature.
The reaction mixture was filtered and concentrated in vacuo.
The residue was purified by column chromatography (silica, petroleum ether/ethyl acetate=6/1) to give ethyl 5-acetylisoxazole-3-carboxylate (4.4 g, 24.0 mmol, 89%) as a yellow oil. LCMS (ESI) m/z: 184.1 [M+H]+.
References:
Yumanity Therapeutics, Inc.;WRONA, Iwona;TIVITMAHAISOON, Parcharee;TARDIFF, Daniel;PANDYA, Bhaumik;OZBOYA, Kerem;LUCAS, Matthew;BOURDONNEC, Bertrand Le US2019/330198, 2019, A1 Location in patent:Paragraph 0712
1423-60-5
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14337-43-0
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104776-70-7
50 suppliers
$49.47/250mgs: