Yield:1260763-41-4 81%

Reaction Conditions:

with 1H-imidazole;palladium diacetate;triethylamine;4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;magnesium chloride in tetrahydrofuran at 90; for 0.5 h;Microwave irradiation;

Steps:

To a stirred mixture of aryl or heteroaryl halide(Br, I) (0.5 mmol), potassium mono ethyl malonate (0.75 mmol) in THF (10 mL) taken in a 30 mL microwave vial, was added Pd(OAc)₂(5 mol%), Xantphos (5 mol %), MgCl₂ (0.75), Et₃N ( 0.75mmol), imidazole (1 mmol) followed by Co₂(CO)₈ (0.15mmol). The vial was sealed immediately and microwave irradiated at 90°C for 30min. The reaction mixture was concentrated and diluted with ethyl acetate and water. The ethyl acetate layer was separated, dried over sodium sulphate and concentrated. The crude product obtained was purified by column chromatography to get the pure compound.

References:

Baburajan, Poongavanam;Elango, Kuppanagounder P. [Tetrahedron Letters,2014,vol. 55,# 25,p. 3525 - 3528] Location in patent:supporting information