ETHYL-2,4-DIMETHYL-5-PYRIMIDINE CARBOXYLATE synthesis
- Product Name:ETHYL-2,4-DIMETHYL-5-PYRIMIDINE CARBOXYLATE
- CAS Number:2226-86-0
- Molecular formula:C9H12N2O2
- Molecular Weight:180.2
Yield:2226-86-0 50%
Reaction Conditions:
with triethylamine in ethanol; for 2 h;Reflux;
Steps:
4.1 Step 1: Ethyl 2,4-dimethylpyrimidine-5-carboxylic acid(D-b)
(E) -2- (ethoxymethylene) -3-oxobutanoic acid ethyl ester Da (22 g, 0.12 mol) was added to a dry 250 mL single-necked flask, dissolved in ethanol (50 mL), and acetamidine ( 10 g, 0.11 mmol) and triethylamine (11 g, 0.11 mol). The reaction solution was heated to reflux and stirred for 2 hours. After the reaction was completed, the ethanol was spin-dried. Purification by column chromatography (ethyl acetate: petroleum ether = 9: 10) gave ethyl 2,4-dimethylpyrimidine-5-carboxylic acid D-b (10 g, 50% yield) as a brown oil.
References:
CN110563722,2019,A Location in patent:Paragraph 0246-0250
141-97-9
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